Generic selectors
Exact matches only
Search in title
Search in content


Frank Löffler, Ph.D.


  • Governor’s Chair Professor in Microbiology



The Loeffler Lab studies relevant biogeochemical processes in soil, sediment, subsurface and water environments by combining cultivation-based techniques with genetic, biochemical, analytical, meta-omics, and computational methodologies. This integrated approach unifies research themes in the Loeffler Lab, and all projects address fundamental research questions, some have an applied component, and several are of considerable public interest.

Read More About the Loeffler Lab >

Relevant Publications:

Orellana, L.H., J.K. Hatt, R. Iyer, K. Chourey, R.L. Hettich, J.C. Spain, W.H. Yang, J.C. Chee-Sanford, R.A. Sanford, F.E. Löffler, and K.T. Konstantinidis. 2019. Comparing DNA, RNA and protein levels for measuring microbial activity in nitrogen-amended soils. Scientific Reports. Accepted.

Lawson, C.E., W.R. Harcombe, R. Hatzenpichler, S.R. Lindemann, F.E. Löffler, M.A. O’Malley, H. García-Martin, B.F. Pfleger, L. Raskin, O.S. Venturelli, D.G. Weissbrodt, D.R. Noguera, and K.D. McMahon. 2019. Unmasking common principles and practices for microbiome engineering. Nature Microbiology. Accepted.

Yan, J., Y. Yang, X. Li, and F.E. Löffler. 2019. Complete genome sequence of Dehalococcoides mccartyi strain FL2, a trichloroethene-respiring anaerobe isolated from pristine freshwater sediment. Microbiology Resource Announcements. Accepted.

Villalobos Solis, M.I., P.E. Abraham, K. Chourey, CM Swift, F.E. Löffler, and R.L. Hettich. 2019. Targeted detection of Dehalococcoides mccartyi microbial protein biomarkers as indicators of reductive dechlorination activity in contaminated groundwater. Scientific Reports, 9:10604 |

Chen, H., Z.K. Yang, D. Yip, R.H. Morris, S.J. Lebreux, M.A. Cregger, D.M. Klingeman, D. Hui, R.L. Hettich, S.W. Wilhelm, G. Wang, F.E. Löffler, and C.W. Schadt. 2019. One-time nitrogen fertilization shifts switchgrass soil microbiomes within a context of larger spatial and temporal variation. PLoS ONE 14(6): e0211310.

Liang X., J. Zhuang, F.E. Löffler, Y. Zhang, J. DeBruyn, S. Wilhelm, S.M. Schaeffer, and M. Radosevich. 2019. Viral and bacterial community responses to stimulated Fe(III)-bioreduction during simulated subsurface bioremediation. Environ. Microbiol. 6:2043-2055 | doi:10.1111/1462-2920.14566.

Yin, Y., Yan, G. Chen, F. Kara Murdoch, N. Pfisterer, and F.E. Löffler. 2019. Nitrous oxide is a potent inhibitor of bacterial reductive dechlorination. Environ. Sci. Technol. 53:692-701. | doi: 10.1021/acs.est.8b05871.

Kleindienst, S., K. Chourey, G. Chen, R. Iyer, R.L. Hettich, S.R. Campagna, E.E. Mack, E.S. Seger, and F.E. Löffler. 2019. Proteogenomics reveals novel reductive dehalogenases and methyltransferases expressed during anaerobic dichloromethane metabolism. Appl. Environ. Microbiol. 85:e02768-18 | doi: 10.1128/AEM.02768-18.

Liang X., M. Radosevich, F.E. Löffler, S.M. Schaeffer, and J. Zhuang. 2019. Impact of microbial iron oxide reduction on the transport of diffusible tracers and non-diffusible nanoparticles in soils. Chemosphere, 220:391-402. |

Contact Info:



Browse More

Helpful Links